Influence of regular exercise on fibrinogen concentration in women with metabolic syndrome
RESUMEN COMUNICACIÓN/PÓSTER
The present study was designed to determine the influence of regular exercise on plasmatic fibrinogen in women with metabolic syndrome. Sixty young women with metabolic syndrome according to the criteria reported by the National Cholesterol Education Program Adult Treatment Panel III volunteered for this study. Fourty-five were randomly included in experimental group to perform a 12-week aerobic training program, 3 days/week, consisting of warm up (10 min), main part (20-35 min [increasing 5 minutes each three weeks]) at a work intensity of 60-75% of peak heart rate (increasing 5% each three weeks) and cool-down (10 min). Control group included 15 age, sex and BMI-matched women with metabolic syndrome that will not perform any training program. Plasmatic fibrinogen was measured using immunoturbidimetric assays. When compared to baseline, plasmatic fibrinogen was decreased significantly after being exercised (386.4±12.1 vs 363±11.4 mg/dl fibrinogen; p<0.05). On the contrary no changes were reported in controls. It may be concluded regular exercise may reduce plasmatic
Introduction:
It is widely accepted individuals with metabolic syndrome presented a hypercoagulable state that may finally result in an increased cardiovascular risk profile. The present study was designed to determine the influence of regular exercise on plasmatic fibrinogen in women with metabolic syndrome.
Methods:
Sixty young women with metabolic syndrome according to the criteria reported by the National Cholesterol Education Program Adult Treatment Panel III volunteered for this study. Fourty-five were randomly included in experimental group to perform a 12- week aerobic training program, 3 days/week, consisting of warm up (10 min), main part (20-35 min [increasing 5 minutes each three weeks]) at a work intensity of 60-75% of peak heart rate (increasing 5% each three weeks) and cool-down (10 min). Control group included 15 age, sex and BMI-matched women with metabolic syndrome that will not perform any training program. Written informed consent was obtained. Further our protocol was approved by an institutional ethic committee. Plasmatic fibrinogen was measured using immunoturbidimetric assays. Both parameters were assessed twice: 72-hours before starting the program (pre-test) and after its ending (posttest).
Results:
When compared to baseline, plasmatic fibrinogen was decreased significantly after being exercised (386.4±12.1 vs 363±11.4 mg/dl fibrinogen; p<0.05). On the contrary no changes were reported in controls.
Conclusions:
It may be concluded regular exercise may reduce plasmatic fibrinogen in women with metabolic syndrome. Further studies are required.
