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14 feb 2008

Variabilities in oxidative stress during prolonged stay in simulated hypoxic environment

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Japan Institute of Sports Sciences (JISS) has equipped with an artificial hypoxic training facilities and accomodations which can simulate altitude training even staying at sea level, as in Tokyo. This resaearch project intended to investigate the effective leverage of these artificial hypoxic devices.

 
Autor(es): Taisuke ENOKI1), Nao OHIWA1) , Mitsuo NEYA2), Takashi KAWAHARA3).
Entidades(es): 1) Department Of Sports Science, Japan Institute Of Sports Sciences. 2)The Graduate School Of Arts And Sciences, The University Of Tokyo. 3) Department Of Sports Medicine, Japan Institute Of Sports Sciences. Japan.
Congreso: I Simposio de Entrenamiento en Altura
Pontevedra: 14-16 de Febrero de 2008
ISBN: 978-84-612-2278-8
Palabras claves: hypoxic training, hypoxic devices

Introduction

Japan Institute of Sports Sciences (JISS) has equipped with an artificial hypoxic training facilities and accomodations which can simulate altitude training even staying at sea level, as in Tokyo. This resaearch project intended to investigate the effective leverage of these artificial hypoxic devices. Thus, the purpose of this study is to comprehend the physical condition of the athletes during prolonged stay in simulated hypoxic environment. We biochemistry lab. focused on the variabilities in oxdative stress during prolonged stay in simulated hypoxic environment.

Materials and Methods

For 30 days in JISS, 10 volunteers (male, college distance runners) stayed in hypoxic accommodations (14.5% O2) and engaged the running training in hypoxic training facilities (14.5% O2). Participants are divided to the following groups – LHTL (Live High Train Low), LHTH (Live High Train High) and LLTL (Live Low Train Low = Control). The samples (blood and urine) were taken on 1, 5, 9, 17 and 29th day. We measured the oxidative stress biomarkers, 8-hydroxydeoxyguanosine (8-OHdG), N-(hexanonyl) lysine (HEL) and glutathione (Glu), by EIA or ELISA method.

Results and discussion

The results were that the oxidative stress 1) increased on the 1st day, 2) once decreased approximate on the 5th day, 3) progressively increased after the 17th day. These results suggest that oxidative stress is not constant but variable during long-term stay in simulated hypoxia.

 

Bibliography

The effects of nightly normobaric hypoxia and high intensity training under intermittent normobaric hypoxia on running economy and hemoglobin mass. Neya M. J Appl Physiol. 2007,103(3):828-34.

Note

8-OHdG has a correlation with the oxidative DNA damages. HEL is identified as an initial biomarker of lipid hydroperoxide from the oxidative stress.

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