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8 may 2006

Lipoperoxidation is increased in obese andalusian adolescents: a previous note

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The present study was undertaken to compare lipoperoxidation in obese and non-obese male adolescents from Andalusia. To get this goal, two hundred seventy male adolescents (age 17.2±0.6) volunteered...
 
Autor(es): Rosety I, Macias-Amat IM, Fornieles G, Rosety MA, Rosety-Rodríguez M, Ordóñez FJ.
Entidades(es): ESCUELA DE MEDICINA DEL DEPORTE. UNIVERSIDAD DE CÁDIZ
Congreso: II Congreso Internacional de las Ciencias del Deporte
Pontevedra:08-10 de Mayo de 2006
ISBN: 978-84-612-3518-6
Palabras claves: LIPOPEROXIDATION, ADOLESCENT, OBESE

RESUMEN COMUNICACIÓN/PÓSTER

The present study was undertaken to compare lipoperoxidation in obese and non-obese male adolescents from Andalusia. To get this goal, two hundred seventy male adolescents (age 17.2±0.6) volunteered for this study. Two hundred fourty of them were obese (BMI=33.8±2.9 kg/m2; BF=36.2±4.6%) and were randomly selected from. Control group included 30 age and sex-matched adolescents (BMI=22.1±1.8 kg/m2; BF=25.7±4.2%). No one of them reported neither toxic habits (smoking or alcohol) nor antioxidant consumption. The level of malondialdehyde (MDA) reflecting the status of the lipid peroxidation process, was assayed in plasma by high performance liquid chromatography (HPLC) with fluorimetric detection as described elsewhere. Fat mass percentage was determined by bioelectrical impedance analysis. Written informed consent was obtained from all their parents. Further our protocol was approved by an institutional ethic committee. When compared to controls, plasmatic malondialdehyde concentration was lower in obese adolescents (0.37±0.11 vs 0.21±0.08 ?mol·l-1 MDA; p<0.05). Lipoperoxidation in obese adolescents was increased when compared to non-obese controls. Further studies on this topic are highly required.

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Introduction

Obesity is a major public health problem not only in adulthood but also at early life stages. Recents studies have reported a sinificant association between obesity and oxidative damage in adults. However little information is available regarding the association of obesity and oxidative damage at early lisfe stages. Accordingly, research on this topic may be of great interest since oxidative damage has been proposed as a pathogenic mechanism of atherosclerosis, cell aging, neurodegeneration, carcinogenic events and immunological disorders among others. Consequently, the present study was undertaken to compare lipoperoxidation in obese and nonobese male adolescents from Andalusia.

Methods:

Two hundred seventy male adolescents (age 17.2±0.6) volunteered for this study. Two hundred fourty of them were obese (BMI=33.8±2.9 kg/m2; BF=36.2±4.6%) and were randomly selected from. Control group included 30 age and sex-matched adolescents (BMI=22.1±1.8 kg/m2; BF=25.7±4.2%). No one of them reported neither toxic habits (smoking or alcohol) nor antioxidant consumption. The level of malondialdehyde (MDA) reflecting the status of the lipid peroxidation process, was assayed in plasma by high performance liquid chromatography (HPLC) with fluorimetric detection as described elsewhere. Fat mass percentage was determined by bioelectrical impedance analysis. Written informed consent was obtained from all their parents. Further our protocol was approved by an institutional ethic committee.

Results:

When compared to controls, plasmatic malondialdehyde concentration was lower in obese adolescents (0.37±0.11 vs 0.21±0.08 ?mol·l-1 MDA; p<0.05).

Conclusion:

Lipoperoxidation in obese adolescents was increased when compared to non-obese controls. Further studies on this topic are highly required.

 

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